Some Week 6 games were played before this article was published. Those games are listed as Results rather than Predictions and will not count toward the prediction record. All other games are official Week 6 predictions.
Week 6 — Games Before Predictions
Tuesday Slate, October 6
5:00 PM PT — ESPN2
Southern Miss (1–3) at Troy (2–2)
Location: Veterans Memorial Stadium — Troy, AL
Result: Troy 55–34
Wednesday Slate, October 7
4:00 PM PT — CBS Sports Network
Jacksonville State (3–2) at Kennesaw State (1–4)
Location: Walens Family Field at Fifth Third Stadium — Kennesaw, GA
Result: Jacksonville State 27–26
4:30 PM PT — ESPN2
New Mexico State (2–3) at FIU (2–2)
Location: Pitbull Stadium — Miami, FL
Result: FIU 22–3
Thursday Slate, October 8
4:00 PM PT — ESPNU
Sam Houston (1–3) at Liberty (4–1)
Location: Williams Stadium — Lynchburg, VA
Prediction: Liberty 42–24
4:00 PM PT — CBS Sports Network
Missouri State (1–3) at Western Kentucky (1–4)
Location: Houchens Industries-L.T. Smith Stadium — Bowling Green, KY
Prediction: Western Kentucky 31–28
4:30 PM PT — ESPN
South Florida (4–1) at UTSA (4–1)
Location: Alamodome — San Antonio, TX
Prediction: UTSA 31–24
4:30 PM PT — ESPN2
South Alabama (3–2) at Arkansas State (2–3)
Location: Centennial Bank Stadium — Jonesboro, AR
Prediction: South Alabama 24–20
Friday Slate, October 9
4:00 PM PT — ESPN
Florida State (3–2) at Louisville (2–3)
Location: L&N Federal Credit Union Stadium — Louisville, KY
Prediction: Florida State 27–20
6:00 PM PT — FOX
#20 Iowa (4–1) at Washington (3–2)
Location: Alaska Airlines Field at Husky Stadium — Seattle, WA
Prediction: Iowa 24–14
6:00 PM PT — The CW
Washington State (1–4) at Utah State (1–4)
Location: Merlin Olsen Field at Maverik Stadium — Logan, UT
Prediction: Washington State 28–24
6:00 PM PT — CBS Sports Network
Wyoming (2–3) at San Jose State (3–2)
Location: CEFCU Stadium — San Jose, CA
Prediction: San Jose State 38–20
7:15 PM PT — ESPN
Iowa State (3–2) at #8 BYU (4–0)
Location: LaVell Edwards Stadium — Provo, UT
Prediction: BYU 38–17
Saturday Morning Slate, October 10
9:00 AM PT — FOX
#7 Indiana (5–0) at Nebraska (5–0)
Location: Tom Osborne Field at Memorial Stadium — Lincoln, NE
Prediction: Indiana 35–20
This is an absolutely huge matchup between two undefeated Big 10 teams.
9:00 AM PT — ABC
Texas A&M (3–2) at #14 Missouri (4–1)
Location: Memorial Stadium at Faurot Field — Columbia, MO
Prediction: Missouri 38–21
9:00 AM PT — ESPN2
UCF (3–2) at #18 Oklahoma State (3–1)
Location: Boone Pickens Stadium — Stillwater, OK
Prediction: Oklahoma State 42–20
9:00 AM PT — ESPN
North Carolina (2–2) at #25 Pittsburgh (5–0)
Location: Acrisure Stadium — Pittsburgh, PA
Prediction: North Carolina 28–24
9:00 AM PT — TNT
Arizona (4–1) at West Virginia (3–2)
Location: Milan Puskar Stadium — Morgantown, WV
Prediction: Arizona 38–28
9:00 AM PT — The CW
Wake Forest (4–1) at NC State (3–2)
Location: Carter-Finley Stadium — Raleigh, NC
Prediction: Wake Forest 31–21
9:00 AM PT — CBS Sports Network
Tulane (2–2) at Army (2–2)
Location: Michie Stadium — West Point, NY
Prediction: Army 28–21
9:00 AM PT — ESPN+
Sacramento State (1–4) at Bowling Green (1–4)
Location: Doyt L. Perry Stadium — Bowling Green, OH
Prediction: Bowling Green 24–21
9:30 AM PT — Big Ten Network
Ball State (1–4) at Northwestern (3–1)
Location: Ryan Field — Evanston, IL
Prediction: Northwestern 42–14
9:45 AM PT — SEC Network
South Carolina (2–3) at #16 Florida (4–1)
Location: Ben Hill Griffin Stadium — Gainesville, FL
Prediction: Florida 35–21
10:00 AM PT — ESPN+
Old Dominion (2–3) at Appalachian State (3–2)
Location: Kidd Brewer Stadium — Boone, NC
Prediction: Appalachian State 30–27
11:00 AM PT — ESPN+
Miami (Ohio) (3–2) at UMass (4–1)
Location: Warren P. McGuirk Alumni Stadium — Amherst, MA
Prediction: UMass 28–27
Afternoon Slate
12:30 PM PT — FOX
#1 Texas (4–0) vs. Oklahoma (2–2)
Location: Cotton Bowl — Dallas, TX
Prediction: Texas 28–21
12:30 PM PT — NBC
Stanford (2–3) at #3 Notre Dame (5–0)
Location: Notre Dame Stadium — South Bend, IN
Prediction: Notre Dame 42–17
12:30 PM PT — ESPN
#9 Ole Miss (3–1) at Vanderbilt (3–2)
Location: FirstBank Stadium — Nashville, TN
Prediction: Ole Miss 38–17
12:30 PM PT — CBS
#21 UCLA (4–0) at #13 Oregon (3–1)
Location: Autzen Stadium — Eugene, OR
Prediction: Oregon 35–24
In a West Coast clash, expect a hotly contested matchup between familiar foes. UCLA has been a pleasant surprise under first-year head coach Bob Chesney. They are much improved from a year ago and are rolling to start the year. Wayne Knight has been excellent and is leading a great running game. Defensively, they have been able to force turnovers and cause problems for opposing quarterbacks. The Ducks have been asserting themselves since the injury to Dante Moore after a scary hit. Dylan Raiola has stepped in and performed at an incredibly high level and will need to continue that level of play. Oregon’s defense has started to find its stride over the last couple of weeks, which should greatly benefit them in the game. Look for the Ducks to limit the rushing attack of the Bruins and put up a ton of points as they walk away with the win.
12:30 PM PT — FOX
#22 Houston (4–1) at Kansas State (3–1)
Location: Bill Snyder Family Stadium — Manhattan, KS
Prediction: Houston 34–28
Houston is coming into this road game against Kansas State as an underdog, which seems weird when they are the ones who are ranked. The Cougars have experience on offense and a reliable defense. With players such as Makhi Hughes, Amare Thomas, and Conner Weigman, the Cougars can score with anyone. Kansas State is coming off a tough loss to Cincinnati, and I wonder if that is still on their mind. Avery Johnson is the heartbeat of this team; the better he plays, the likelihood of victory goes up as well. Other Wildcats on both sides of the ball will need to step up, and even if they do, Houston is no slouch. With that being said, my pick is the Cougars to win by one score on the road.
12:30 PM PT — FS1
Illinois (2–3) at Michigan State (2–3)
Location: Spartan Stadium — East Lansing, MI
Prediction: Michigan State 20–17
12:30 PM PT — ESPN2
Duke (4–0) at Georgia Tech (1–3)
Location: Bobby Dodd Stadium at Hyundai Field — Atlanta, GA
Prediction: Duke 42–10
12:30 PM PT — ESPN2
Virginia Tech (4–1) at California (2–3)
Location: California Memorial Stadium — Berkeley, CA
Prediction: Virginia Tech 28–21
12:30 PM PT — ESPN+
Charlotte (0–5) at North Texas (3–2)
Location: DATCU Stadium — Denton, TX
Prediction: North Texas 42–10
12:30 PM PT — CBS Sports Network
Tulsa (3–2) at Navy (1–3)
Location: Navy-Marine Corps Memorial Stadium — Annapolis, MD
Prediction: Tulsa 31–20
12:45 PM PT — ESPNU
UConn (2–3) at Temple (2–3)
Location: Lincoln Financial Field — Philadelphia, PA
Prediction: Temple 31–27
1:00 PM PT — ESPN+
Rice (1–4) at East Carolina (2–2)
Location: Dowdy-Ficklen Stadium — Greenville, NC
Prediction: East Carolina 24–17
1:00 PM PT — ESPN+
Eastern Michigan (3–3) at Akron (1–4)
Location: InfoCision Stadium-Summa Health Field — Akron, OH
Prediction: Eastern Michigan 28–17
1:00 PM PT — ESPN+
Central Michigan (3–2) at Ohio (3–2)
Location: Peden Stadium — Athens, OH
Prediction: Central Michigan 28–21
1:00 PM PT — ESPN+
Buffalo (2–3) at Toledo (4–1)
Location: Glass Bowl — Toledo, OH
Prediction: Toledo 38–21
1:00 PM PT — ESPN+
Kent State (2–3) at Western Michigan (3–2)
Location: Waldo Stadium — Kalamazoo, MI
Prediction: Western Michigan 24–20
1:15 PM PT — Big Ten Network
Maryland (2–3) at #5 Ohio State (4–1)
Location: Ohio Stadium — Columbus, OH
Prediction: Ohio State 49–14
1:15 PM PT — SEC Network
#15 Tennessee (4–1) at Arkansas (2–3)
Location: Donald W. Reynolds Razorback Stadium — Fayetteville, AR
Prediction: Tennessee 35–20
3:00 PM PT — USA Network
San Diego State (2–3) at Oregon State (3–2)
Location: Reser Stadium — Corvallis, OR
Prediction: Oregon State 42–21
Evening Slate
4:00 PM PT — ESPN
#10 LSU (4–1) at Kentucky (4–1)
Location: Kroger Field — Lexington, KY
Prediction: LSU 31–20
4:00 PM PT — FS1
Nevada (1–3) at UTEP (1–4)
Location: Sun Bowl — El Paso, TX
Prediction: UTEP 27–21
4:00 PM PT — ESPN2
UAB (3–2) at Memphis (4–1)
Location: Simmons Bank Liberty Stadium — Memphis, TN
Prediction: Memphis 42–21
4:00 PM PT — ESPN+
Coastal Carolina (1–4) at Marshall (3–2)
Location: Joan C. Edwards Stadium — Huntington, WV
Prediction: Marshall 34–24
4:10 PM PT — The CW
North Dakota State (5–0) at UNLV (3–2)
Location: Allegiant Stadium — Las Vegas, NV
Prediction: North Dakota State 35–31
4:30 PM PT — ABC
#2 Georgia (5–0) at #6 Alabama (5–0)
Location: Bryant-Denny Stadium — Tuscaloosa, AL
Prediction: Alabama 31–27
In the game of the week, two top-10 teams will clash in Tuscaloosa. This matchup has been a bit of a one-sided rivalry in recent years. The head man for the Bulldogs, Kirby Smart, has particularly struggled in their previous games. Georgia is led by fifth-year quarterback Gunner Stockton, who has a tendency to show up when the moment matters most. He will need to do so as Alabama has been improving on a weekly basis. Their young quarterback, Keelon Russell, has thrust his name into the Heisman conversation with his superb play as of late. The winner of this game will greatly impact the conference championship and playoff picture. This game should come down to the wire, as the Crimson Tide will win at home in front of a raucous crowd.
4:30 PM PT — NBC
#19 USC (5–1) at Penn State (3–2)
Location: Beaver Stadium — University Park, PA
Prediction: USC 35–30
The Trojans look to return to their winning ways as they travel to an intense environment to play against a tough Penn State team. Aside from their loss to Oregon, USC has been explosively offensive and has withstood every punch thrown their way. Jayden Maiava has looked exceptional and looks primed to show why he should be a Heisman candidate. Expect them to have their hands full with Penn State. The Nittany Lions are a much better team at home and have something to prove to the home fans. This matchup depends on whether or not Penn State’s offense can keep up with USC’s. I anticipate this one to be a tight game, with the victory going to the Trojans.
4:30 PM PT — ACC Network
Syracuse (2–2) at Virginia (3–2)
Location: Scott Stadium — Charlottesville, VA
Prediction: Virginia 28–24
4:30 PM PT — CBS Sports Network
Air Force (3–1) at Northern Illinois (0–4)
Location: Huskie Stadium — DeKalb, IL
Prediction: Air Force 27–14
4:30 PM PT — ESPNU
James Madison (5–0) at Georgia Southern (2–3)
Location: Allen E. Paulson Stadium — Statesboro, GA
Prediction: James Madison 38–21
4:30 PM PT — ESPN+
Louisiana (4–1) at Louisiana Tech (2–2)
Location: Joe Aillet Stadium — Ruston, LA
Prediction: Louisiana 42–28
5:00 PM PT — Big Ten Network
Minnesota (4–1) at Purdue (2–3)
Location: Ross-Ade Stadium — West Lafayette, IN
Prediction: Minnesota 35–30
Night Slate
7:15 PM PT — ESPN
Kansas (2–2) at #12 Utah (4–0)
Location: Rice-Eccles Stadium — Salt Lake City, UT
Prediction: Utah 38–17
7:30 PM PT — FS1
Hawai’i (1–3) at Arizona State (2–2)
Location: Mountain America Stadium — Tempe, AZ
Prediction: Arizona State 42–20
7:30 PM PT — The CW
#23 Boise State (4–1) at Fresno State (4–1)
Location: Valley Children’s Stadium — Fresno, CA
Prediction: Boise State 31–27
I expect Pac-12 After Dark to be in full effect as two of the top teams in the conference battle it out with potential conference championship implications on the line. The Broncos are led by Dylan Riley, who has rushed for nearly 700 yards this season. Over his last three games, he has scored three rushing touchdowns and has continued to be a major part of the Broncos’ offense. Fresno State will need their electric wide receiver, Josiah Freeman. He has the potential to exploit the Boise State defense, as they allow over 370 yards per game. Whichever team’s star has more of an impact on this game will win. I expect Riley and the Broncos to outscore the Bulldogs in a late-night showdown.
