Powerful Week 1 Game Picks for 2026 College Football

Thursday, September 3

3:00 PM — BTN

UMass (0–0) at Rutgers (0–0)

Location: SHI Stadium — Piscataway, New Jersey

Prediction: Rutgers 38–10

4:00 PM — ACC Network

Akron (0–0) at Wake Forest (0–0)

Location: Allegacy Federal Credit Union Stadium — Winston-Salem, North Carolina

Prediction: Wake Forest 42–10

4:00 PM — ESPN+

UAlbany at Buffalo (0–0)

Location: Broadview Stadium — Amherst, New York

Prediction: Buffalo 31–14

4:00 PM — ESPN+

Merrimack at Delaware (0–0)

Location: Tubby Raymond Field at Delaware Stadium — Newark, Delaware

Prediction: Delaware 42–17

4:00 PM — ESPN+

Bethune-Cookman at UCF (0–0)

Location: Acrisure Bounce House — Orlando, Florida

Prediction: UCF 42–3

4:00 PM — ESPN+

West Georgia at Kennesaw State (0–0)

Location: Fifth Third Stadium — Kennesaw, Georgia

Prediction: Kennesaw State 35–17

5:00 PM — Peacock

Eastern Illinois at Minnesota (0–0)

Location: Huntington Bank Stadium — Minneapolis, Minnesota

Prediction: Minnesota 49–10

5:00 PM — ESPN

Colorado (0–0) at Georgia Tech (0–0)

Location: Bobby Dodd Stadium at Hyundai Field — Atlanta, Georgia

Prediction: Georgia Tech 31–21

Georgia Tech is going to win this game in large part because of its running game. With a new quarterback who has limited starting experience, expect the Yellow Jackets to hand the ball to their running backs early and often. There are plenty of questions surrounding the Buffaloes’ defense, especially with all 11 projected defensive starters coming from the transfer portal. I have doubts about the continuity of this defense, particularly with so many new players being asked to come together right away. Georgia Tech will get up early and not look back as the Yellow Jackets cruise to a 10-point victory at home.

5:00 PM — SEC Network

Arkansas-Pine Bluff at #25 Missouri (0–0)

Location: Memorial Stadium at Faurot Field — Columbia, Missouri

Prediction: Missouri 45–9

6:00 PM — BTN

UAB (0–0) at Illinois (0–0)

Location: Memorial Stadium — Champaign, Illinois

Prediction: Illinois 35–10

6:00 PM — ESPNU

Idaho at #21 Utah (0–0)

Location: Rice-Eccles Stadium — Salt Lake City, Utah

Prediction: Utah 42–7

Friday, September 4

3:30 PM — ESPN+

San Jose State (0–1) at Eastern Michigan (1–0)

Location: Rynearson Stadium — Ypsilanti, Michigan

Prediction: San Jose State 38–31

4:00 PM — BTN

Indiana State at Purdue (0–0)

Location: Ross-Ade Stadium — West Lafayette, Indiana

Prediction: Purdue 28–3

4:00 PM — ESPN+

North Carolina A&T at Georgia State (0–0)

Location: Center Parc Stadium — Atlanta, Georgia

Prediction: Georgia State 33–10

5:00 PM — FS1

Toledo (0–0) at Michigan State (0–0)

Location: Spartan Stadium — East Lansing, Michigan

Prediction: Michigan State 38–25

5:00 PM — ESPNU

LIU at Kansas (0–0)

Location: David Booth Kansas Memorial Stadium — Lawrence, Kansas

Prediction: Kansas 42–10

5:00 PM — SEC Network+

UTEP (0–0) at #10 Oklahoma (0–0)

Location: Gaylord Family-Oklahoma Memorial Stadium — Norman, Oklahoma

Prediction: Oklahoma 52–7

6:00 PM — FOX

Fresno State (0–0) at #14 USC (1–0)

Location: United Airlines Field at the Los Angeles Memorial Coliseum — Los Angeles, California

Prediction: USC 49–14

6:00 PM — ESPN

#7 Miami (0–0) at Stanford (1–0)

Location: Stanford Stadium — Stanford, California

Prediction: Miami 42–17

Saturday, September 5 — Morning Slate

9:00 AM — FOX

North Texas (0–0) at #6 Indiana (0–0)

Location: Memorial Stadium — Bloomington, Indiana

Prediction: Indiana 49–14

9:00 AM — ABC

East Carolina (0–0) at #13 Alabama (0–0)

Location: Bryant-Denny Stadium — Tuscaloosa, Alabama

Prediction: Alabama 42–3

9:00 AM — ESPN

Oregon State (0–0) at #23 Houston (0–0)

Location: TDECU Stadium — Houston, Texas

Prediction: Houston 38–10

9:00 AM — TNT

Coastal Carolina (0–0) at West Virginia (0–0)

Location: Milan Puskar Stadium — Morgantown, West Virginia

Prediction: West Virginia 35–17

9:00 AM — ACC Network

New Hampshire at Syracuse (0–0)

Location: JMA Wireless Dome — Syracuse, New York

Prediction: Syracuse 45–10

9:00 AM — FS1

Ohio (0–0) at Nebraska (0–0)

Location: Tom Osborne Field at Memorial Stadium — Lincoln, Nebraska

Prediction: Nebraska 27–3

9:00 AM — ESPN+

Lafayette at UConn (0–0)

Location: Pratt & Whitney Stadium at Rentschler Field — East Hartford, Connecticut

Prediction: UConn 28–10

9:00 AM — CBS Sports Network

Bryant at Army (0–0)

Location: Blaik Field at Michie Stadium — West Point, New York

Prediction: Army 31–7

9:00 AM — ESPN+

Tarleton State at Bowling Green (0–0)

Location: Doyt L. Perry Stadium — Bowling Green, Ohio

Prediction: Bowling Green 24–17

9:00 AM — ESPNU

Liberty (0–0) at James Madison (0–0)

Location: Showker Field at Bridgeforth Stadium — Harrisonburg, Virginia

Prediction: James Madison 27–17

9:30 AM — BTN

Ball State (0–0) at #1 Ohio State (0–0)

Location: Ohio Stadium — Columbus, Ohio

Prediction: Ohio State 63–7

9:30 AM — The CW

Miami (OH) (0–0) at Pittsburgh (0–0)

Location: Acrisure Stadium — Pittsburgh, Pennsylvania

Prediction: Pittsburgh 33–14

9:45 AM — SEC Network

Kent State (0–0) at South Carolina (0–0)

Location: Williams-Brice Stadium — Columbia, South Carolina

Prediction: South Carolina 45–10

10:00 AM — ESPN+

Southeast Missouri State at Iowa State (0–0)

Location: Jack Trice Stadium — Ames, Iowa

Prediction: Iowa State 33–10

10:00 AM — MW

Duquesne at Air Force (0–0)

Location: Falcon Stadium — Colorado Springs, Colorado

Prediction: Air Force 31–10

10:00 AM — SEC Network+

Youngstown State at Kentucky (0–0)

Location: Kroger Field — Lexington, Kentucky

Prediction: Kentucky 42–3

11:00 AM — ESPN+

Rhode Island at Temple (0–0)

Location: Lincoln Financial Field — Philadelphia, Pennsylvania

Prediction: Temple 30–14

Saturday, September 5 — Afternoon Slate

12:00 PM — SEC Network+

Tennessee State at #3 Georgia (0–0)

Location: Sanford Stadium — Athens, Georgia

Prediction: Georgia 49–0

12:30 PM — ESPN

Texas State (0–0) at #5 Texas (0–0)

Location: Darrell K Royal–Texas Memorial Stadium — Austin, Texas

Prediction: Texas 42–10

12:30 PM — SEC Network+

Furman at #20 Tennessee (0–0)

Location: Neyland Stadium — Knoxville, Tennessee

Prediction: Tennessee 45–10

12:30 PM — ABC

Baylor (0–0) vs. Auburn (0–0)

Location: Mercedes-Benz Stadium — Atlanta, Georgia

Prediction: Auburn 27–24

This should be one of the weekend’s most hotly contested matchups. Additionally, both teams want to set the tone and show their early season value. With new head coach Alex Golesh and quarterback Byrum Brown, Auburn aims to prove SEC effectiveness. However, Baylor must answer questions on defense, potentially making this game higher scoring than expected. GameDay Picks notes DJ Lagway could be the X factor for Baylor and the game’s swing. If he does, he will prove me wrong with this pick.

12:30 PM — CBS

Boise State (0–0) at #2 Oregon (0–0)

Location: Autzen Stadium — Eugene, Oregon

Prediction: Oregon 49–14

The Ducks will be a force to be reckoned with all season long. They will establish a strong and balanced attack that will cause problems at all levels for the Broncos’ defense. The last time a Boise State team played at Autzen Stadium, the Broncos almost came away with a win behind Ashton Jeanty, who ran absolutely wild against the Ducks. Unfortunately for Bronco fans, they no longer have Jeanty to keep them in this game. Aside from struggling to contain the Ducks’ offense, Boise State will not be able to consistently score against this Oregon defense. The Ducks will walk away with a convincing win to start the 2026 season.

12:30 PM — ESPN+

Maine at Appalachian State (0–0)

Location: Kidd Brewer Stadium — Boone, North Carolina

Prediction: Appalachian State 42–10

12:30 PM — FOX

Boston College (0–0) at Cincinnati (0–0)

Location: Nippert Stadium — Cincinnati, Ohio

Prediction: Boston College 24–21

12:30 PM — FS1

Marshall (0–0) at #18 Penn State (0–0)

Location: Beaver Stadium — University Park, Pennsylvania

Prediction: Penn State 38–14

12:30 PM — ACC Network

Tulane (0–0) at Duke (0–0)

Location: Brooks Field at Wallace Wade Stadium — Durham, North Carolina

Prediction: Duke 30–20

12:30 PM — ESPN+

The Citadel at Charlotte (0–0)

Location: Jerry Richardson Stadium — Charlotte, North Carolina

Prediction: Charlotte 28–10

12:30 PM — CBS Sports Network

Towson at Navy (0–0)

Location: Navy-Marine Corps Memorial Stadium — Annapolis, Maryland

Prediction: Navy 42–7

12:30 PM — ESPN+

UT Rio Grande Valley at UTSA (0–0)

Location: Alamodome — San Antonio, Texas

Prediction: UTSA 38–7

12:30 PM — ESPN+

Murray State at Middle Tennessee (0–0)

Location: Johnny “Red” Floyd Stadium — Murfreesboro, Tennessee

Prediction: Middle Tennessee 28–14

12:45 PM — ESPNU

Oklahoma State (0–0) at Tulsa (0–0)

Location: H.A. Chapman Stadium — Tulsa, Oklahoma

Prediction: Oklahoma State 45–14

1:15 PM — BTN

Northern Illinois (0–0) at #22 Iowa (0–0)

Location: Kinnick Stadium — Iowa City, Iowa

Prediction: Iowa 31–3

1:15 PM — SEC Network

North Alabama at Arkansas (0–0)

Location: Donald W. Reynolds Razorback Stadium — Fayetteville, Arkansas

Prediction: Arkansas 34–6

2:00 PM — ESPN+

Alcorn State at Southern Miss (0–0)

Location: M.M. Roberts Stadium — Hattiesburg, Mississippi

Prediction: Southern Miss 30–7

3:00 PM — ESPN+

Norfolk State at Old Dominion (0–0)

Location: S.B. Ballard Stadium — Norfolk, Virginia

Prediction: Old Dominion 31–7

3:00 PM — USA Network

Wyoming (0–0) at Colorado State (0–0)

Location: Canvas Stadium — Fort Collins, Colorado

Prediction: Colorado State 24–17

4:00 PM — ESPN+

Arkansas State (0–0) at Memphis (0–0)

Location: Simmons Bank Liberty Stadium — Memphis, Tennessee

Prediction: Memphis 42–10

4:00 PM — FS1

Abilene Christian at #12 Texas Tech (0–0)

Location: Jones AT&T Stadium — Lubbock, Texas

Prediction: Texas Tech 52–7

4:00 PM — ESPN

Missouri State at #8 Texas A&M (0–0)

Location: Kyle Field — College Station, Texas

Prediction: Texas A&M 49–3

4:00 PM — ESPN+

Nicholls at Kansas State (0–0)

Location: Bill Snyder Family Stadium — Manhattan, Kansas

Prediction: Kansas State 45–10

4:00 PM — ESPN+

Houston Christian at Rice (0–0)

Location: Rice Stadium — Houston, Texas

Prediction: Rice 38–7

4:00 PM — CBS Sports Network

Idaho State at Utah State (0–0)

Location: Merlin Olsen Field at Maverik Stadium — Logan, Utah

Prediction: Utah State 24–17

4:00 PM — SEC Network+

Austin Peay at Vanderbilt (0–0)

Location: FirstBank Stadium — Nashville, Tennessee

Prediction: Vanderbilt 35–14

4:00 PM — ESPN+

FIU (0–0) at South Florida (0–0)

Location: Raymond James Stadium — Tampa, Florida

Prediction: USF 35–24

4:00 PM — ESPN+

Eastern Kentucky at Jacksonville State (0–1)

Location: AmFirst Stadium — Jacksonville, Alabama

Prediction: Jacksonville State 28–17

4:00 PM — ESPN+

Charleston Southern at Georgia Southern (0–0)

Location: Allen E. Paulson Stadium — Statesboro, Georgia

Prediction: Georgia Southern 27–10

4:00 PM — ESPN+

Southeastern Louisiana at South Alabama (0–0)

Location: Hancock Whitney Stadium — Mobile, Alabama

Prediction: South Alabama 31–17

4:00 PM — ESPN+

Sam Houston (0–0) at Troy (0–0)

Location: Veterans Memorial Stadium — Troy, Alabama

Prediction: Troy 35–21

Saturday, September 5 — Evening Slate

4:30 PM — ABC

Clemson (0–0) at #11 LSU (0–0)

Location: Tiger Stadium — Baton Rouge, Louisiana

Prediction: LSU 38–24

In this matchup between Clemson and LSU, there are numerous storylines that can draw anyone in. Whether it be the battle of elite coaches, the implications for the season, or the talent-laden rosters, this game has everything a fan can enjoy. Clemson will have to worry about traveling to an intense environment with a quarterback who has limited experience as a starter. This could lead to struggles early, benefiting LSU. The LSU Tigers have one of the most talented rosters in the country and should expect to improve this year. Sam Leavitt will put up huge numbers this season, and this game is no different. His efforts on offense and the tough-nosed defense by LSU will give them the edge in this one.

4:30 PM — NBC

Western Michigan (0–0) at #16 Michigan (0–0)

Location: Michigan Stadium — Ann Arbor, Michigan

Prediction: Michigan 42–10

4:30 PM — ACC Network

VMI at Virginia Tech (0–0)

Location: Lane Stadium/Worsham Field — Blacksburg, Virginia

Prediction: Virginia Tech 38–7

4:30 PM — ESPNU

UL Monroe (0–0) at Mississippi State (0–0)

Location: Davis Wade Stadium at Scott Field — Starkville, Mississippi

Prediction: Mississippi State 35–7

4:30 PM — ESPN+

Northwestern State at Louisiana Tech (0–0)

Location: Joe Aillet Stadium — Ruston, Louisiana

Prediction: Louisiana Tech 28–7

4:45 PM — SEC Network

Florida Atlantic (0–0) at Florida (0–0)

Location: Ben Hill Griffin Stadium — Gainesville, Florida

Prediction: Florida 42–10

5:00 PM — BTN

Hampton at Maryland (0–0)

Location: SECU Stadium — College Park, Maryland

Prediction: Maryland 42–14

5:00 PM — ESPN+

Utah Tech at #14 BYU (0–0)

Location: LaVell Edwards Stadium — Provo, Utah

Prediction: BYU 49–7

5:00 PM — BTN

South Dakota State at Northwestern (0–0)

Location: Northwestern Medicine Field at Martin Stadium — Evanston, Illinois

Prediction: Northwestern 31–17

5:00 PM — ESPN+

Lamar at Louisiana (0–0)

Location: Our Lady of Lourdes Stadium — Lafayette, Louisiana

Prediction: Louisiana 21–7

6:00 PM — ESPN+

Mercyhurst at New Mexico State (0–1)

Location: Aggie Memorial Stadium — Las Cruces, New Mexico

Prediction: New Mexico State 30–7

6:30 PM — USA Network

Portland State at San Diego State (0–0)

Location: Snapdragon Stadium — San Diego, California

Prediction: San Diego State 45–17

6:30 PM — ESPN+

Northern Arizona at Arizona (0–0)

Location: Arizona Stadium — Tucson, Arizona

Prediction: Arizona 42–7

Saturday, September 5 — Night Slate

7:00 PM — ESPN+

Morgan State at Arizona State (0–0)

Location: Mountain America Stadium — Tempe, Arizona

Prediction: Arizona State 38–7

7:00 PM — ESPN+

Mississippi Valley State at Sacramento State (0–1)

Location: Hornet Stadium — Sacramento, California

Prediction: Sacramento State 31–14

7:00 PM — The CW

UNLV (0–1) at Hawaiʻi (0–1)

Location: Clarence T.C. Ching Athletics Complex — Honolulu, Hawaii

Prediction: UNLV 42–38

7:00 PM — FS1

Central Michigan (0–0) at New Mexico (0–0)

Location: University Stadium — Albuquerque, New Mexico

Prediction: New Mexico 27–20

7:30 PM — ESPN

UCLA (0–0) at California (0–0)

Location: California Memorial Stadium — Berkeley, California

Prediction: Cal 34–30

In a minor throwback from a few years ago when both teams were in the PAC-12, I expect the Cal Bears to get the job done in a high-scoring Wild West shootout. This game is truly exciting because of the similarities. They both have new coaches, have an electric Hawaiian quarterback, and will rely on new additions to make an impact this season. Whichever team can assert themselves in the trenches and whichever quarterback plays better will win this game. I believe the Bears will get the best of the Bruins in these areas and beat their in-state rival at home.

7:30 PM — CBS Sports Network

Western Kentucky (0–0) at Nevada (0–0)

Location: Mackay Stadium — Reno, Nevada

Prediction: Nevada 27–21

Sunday, September 6

1:00 PM — NBC/Peacock

Washington State (0–0) at #17 Washington (0–0)

Location: Husky Stadium — Seattle, Washington

Prediction: Washington State 31–24

In a shocking upset, the Cougars go into Seattle and steal a victory from their archrival. The Huskies have a great team, but no one knows what can happen in a rivalry game. Recently, Washington State has been successful in winning three of the last four Apple Cup games in Seattle. The new coaching staff, the new schemes, and a slew of new players will cause problems for Washington to plan around effectively. I expect these two teams to battle on each and every play because nothing is sweeter than beating your rival, something the Cougars will enjoy in their first-ever Week 1 matchup against the Huskies.

4:30 PM — ABC

#24 Louisville (0–0) vs. #9 Ole Miss (0–0)

Location: Nissan Stadium — Nashville, Tennessee

Prediction: Ole Miss 31–28

The Ole Miss Rebels are under a new regime with Pete Golding taking the helm full time after a great postseason run. The Rebels return Trinidad Chambliss and Kewan Lacy, which gives them two focal points to focus on all night. If their tough defense can get after Louisville quarterback Lincoln Kienholz, the Ohio State transfer, the Cardinals will struggle. They have Isaac Brown, who is an elite running back that must have a big game if Louisville wants to stand a chance. I believe Ole Miss has too much experience and hangs on late in a close Sunday night matchup.

4:30 PM — NBC/Peacock

Wisconsin (0–0) vs. #4 Notre Dame (0–0)

Location: Lambeau Field — Green Bay, Wisconsin

Prediction: Notre Dame 45–14

Monday, September 7

4:30 PM — ESPN

#19 SMU (0–0) at Florida State (1–0)

Location: Bobby Bowden Field at Doak Campbell Stadium — Tallahassee, Florida

Prediction: SMU 38–17

SMU is coming in with a ton of expectations and is looking to make noise early. They go on the road to play a Seminole team that looked a bit underwhelming in Week 0. Florida State was effective running the ball last week but struggled with its passing game and to score the ball until the fourth quarter. This does not bode well for them, as the Mustangs have one of the best quarterbacks in the conference and a great support system around him. I expect SMU to stroll into Doak Campbell Stadium and win this game easily, securing the first conference win.

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